Clinical Studies

Past and Present

yoonhee-chaYoon-Hee Cha, MD
Assistant Professor
Laureate Institute for Brain Research
Tulsa, Oklahoma
&
Adjunct Assistant Professor
University of California-Los Angeles (UCLA)

In 2010 while at UCLA, Dr. Cha received a three year research grant from the National Institutes of Health (Functional Neuroimaging and Transcranial Magnetic Stimulation in Mal de Debarquement; R03DC010451). Before and subsequent to NIH funding, Dr. Cha also received research grants from the MdDS Balance Disorder Foundation to extend her clinical studies of MdDS. These clinical research investigations have been productive and remain on-going.

Findings from Dr. Cha’s clinical investigations and scholarly activities to address MdDS have been published in the peer-reviewed literature as follows:

Cha YH, Deblieck C, Wu AD. Double-blind sham-controlled crossover trial of repetitive transcranial magnetic stimulation for mal de debarquement syndrome. Otol Neurotol. 37:805-812 2016 May 12. [Epub ahead of print]

Cha YH, Urbano D, Pariseau N. Randomized single blind sham controlled trial of adjunctive home-based tDCS after rTMS for mal de debarquement syndrome: safety, efficacy, and participant satisfaction sssessment. Brain Stimul. 9: 537-44, 2016.

Cha YH, Chakrapani, S. Voxel based morphometry alterations in mal de debarquement syndrome. PLoS One 10:e0135021, 2015.

Cha, YH. Mal de Debarquement Syndrome: new insights. Ann NY Acad Sci. 1343:63-68, 2015.

Shou G, Yuan H, Urbano D, Cha YH, Ding L. Changes of symptom and EEG in mal de debarquement syndrome patients after repetitive transcranial magnetic stimulation over bilateral prefrontal cortex: A pilot study. Conf Proc IEEE Eng Med Biol Soc. 2014:4294-4297, 2014.

Ding L, Shou G, Yuan H, Urbano D, Cha YH. Lasting Modulation Effects of rTMS on Neural Activity and Connectivity as Revealed by Resting State EEG. IEEE Trans Biomed Eng. 61:2070-80, 2014

Cha YH, Cui Y. Rocking dizziness and headache: a two-way street. Cephalalgia. 33:1160-9, 2013.

Cha YH, Cui Y, and Baloh RW. Repetitive transcranial magnetic stimulation for Mal de Debarquement Syndrome. Otol Neurotol. 34:175-9, 2013.

Cha YH. Less common neuro-otologic disorders. Continuum Lifelong Learning in Neurol. 18:1142-1157, 2012.

Cha YH. Mal de Debarquement. Semin Neurol, 29:520-7, 2009. Review.

Cha YH, Brodsky J, Ishiyama G, Sabatti C, Baloh RW. Clinical features and associated syndromes of mal de debarquement. J Neurol, 255:1038-44, 2008.

brianclarkBrian Clark, MD
Professor and Executive Director
Ohio Musculoskeletal and Neurological Institute
Heritage College of Osteopathic Medicine
Ohio University
Athens, Ohio

Dr. Clark received grant support from the MdDS Balance Disorder Foundation to enable early clinical studies focused on MdDS.

The results of Dr. Clark’s MdDS studies have been published in the peer-reviewed literature as follows:

Clark BC, Leporte A, Clark S, Hoffman RL, Quick A, Wilson TE, Thomas JS. Effects of persistent mal de debarquement syndrome on balance, psychological traits, and motor cortex excitability. J Clin Neurosci. 20:446-450, 2013.

Macke A, LePorte A, Clark BC. Social, societal, and economic burden of mal de debarquement syndrome. J Neurol. 259:1326-30, 2012.

Clark BC, Quick A. Exploring the pathophysiology of Mal de Debarquement. J Neurol, 258:1166-8, 2011.

Mingjia Dai, PhD
Assistant Professor
Neurology
Human Balance Laboratory
Icahn School of Medicine at Mount Sinai
New York, NY

In 2012, clinical studies were conducted in the Human Balance Laboratory at the Icahn School of Medicine at Mount Sinai in New York City. Support for this clinical research was provided by the National Institutes of Health (Pilot Study on Mal de Debarquement; R21DC012162).

This study was completed and findings published in July 2014.

Dai M, Cohen B, Smouha E, Cho C. Readaptation of the vestibulo-ocular reflex relieves the mal de debarquement syndrome. Front Neurol. 5:1-6, 2014.

christinedanceyChristine Dancey, PhD
Emeritus Professor
Chronic Illness Research Team (CIRT)
School of Psychology
University of East London
London, UK

From 2010 through 2011, the Chronic Illness Research Team (CIRT) at the University of East London conducted studies to better understand the impact of MdDS on the lives of patients. Research updates provided by CIRT included:

  1. Factors contributing to memory problems in people with MdDS [December 2010; see update]
  2. Perceived stigma, illness intrusiveness, illness uncertainty and quality of life in people with MdDS [Summer 2011; see update]
  3. A qualitative investigation looking at the lived experience of individuals with MdDS – this involved being interviewed [Spring 2012; see update]

The CIRT studies were completed and findings published in October 2014.

Arroll M, Attree E, Cha YH, Dancey C. The relationship between symptom severity, stigma, illness intrusiveness and depression in Mal de Debarquement Syndrome. J Health Psychol. Oct 20. pii:1359105314553046, 2014.

alanpearceAlan M. Pearce, PhD
Senior Research Fellow
Cognitive Neuroscience Laboratory
School of Psychology
Deakin University
Clinical studies designed to determine the efficacy of treatment of MdDS patients with repetitive transcranial magnetic stimulation (rTMS) were also conducted in Australia. The results of these investigations were published in the peer-reviewed literature in 2015.

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